Anti-Myeloid leukemia factor 1 MLF1 Antibody

• Background:

  Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  
  Yoneda-Kato N., Oncogene 12:265-275(1996) [PubMed: 8570204].
  Hanissian S.H., Oncogene 23:3700-3707(2004) [PubMed: 15116101].
  Yoneda-Kato N., EMBO J. 24:1739-1749(2005) [PubMed: 15861129].

• Description:

  Boster Bio Anti-Myeloid leukemia factor 1 MLF1 Antibody (Catalog # A06772) . Tested in WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1; MLF1

• Gene Name:

  MLF1

• UniProt:

  P58340

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from internal of human MLF1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.

• Applications:

  WB

• Field of Research:

  Cancer, Cell Biology, Cell Cycle, Host-Virus Interaction, Interspecies Interaction, Kinases/Phosphatases, Microbiology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  Western blotting: 1:500~1:3000

• Form:

  Liquid

• Function:

  Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. .

• Molecular Weight:

  30627 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Myeloid leukemia factor 1

• Subcellular Location:

  Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus. .