Anti-NUMA1/Numa Antibody

• Background:

  Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
  
  Yang C.H., J. Cell Biol. 116:1303-1317(1992).
  Compton D.A., J. Cell Biol. 116:1395-1408(1992).
  Maekawa T., J. Cell Sci. 105:589-600(1993).

• Description:

  Boster Bio Anti-NUMA1/Numa Antibody (Catalog # A02018) . Tested in WB, IHC applications. This antibody reacts with Human.

• Synonyms:

  Nuclear mitotic apparatus protein 1 ; NuMA protein ; Nuclear matrix protein-22; NMP-22; SP-H antigen ; NUMA1 ; NMP22 , NUMA

• Gene Name:

  NUMA1

• UniProt:

  Q14980

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthesized peptide derived from internal of human NUMA1.

• Clonality:

  Polyclonal

• Applications:

  WB, IHC

• Field of Research:

  Cell Division, Spindle

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume (PubMed:10075938) . Required for maintenance and establishment of the mitotic spindle poles during symmetric cell divisions, functioning as a tether linking bulk microtubules of the spindle to centrosomes (PubMed:7769006, PubMed:11956313, PubMed:26195665) . Also required for proper alignment of the mitotic spindle during asymmetric cell divisions (PubMed:21816348) . .

• Molecular Weight:

  238260 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Nuclear mitotic apparatus protein 1

• Subcellular Location:

  Nucleus matrix . Chromosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Resides in the nuclear matrix during interphase. Dissociates from condensing chromosomes during early prophase and relocates to the spindle poles via dynein/dynamin association; it remains there until the anaphase onset. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. CCSAP is essential for its centrosomal localization (PubMed:26562023) . .