Anti-Protein DBF4 homolog A DBF4 Antibody

• Background:

  Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
  
  Kumagai H., Mol. Cell. Biol. 19:5083-5095(1999).
  Jiang W., EMBO J. 18:5703-5713(1999).
  Ota T., Nat. Genet. 36:40-45(2004).

• Description:

  Boster Bio Anti-Protein DBF4 homolog A DBF4 Antibody (Catalog # A01348-1) . Tested in WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1; DBF4; ASK, DBF4A, ZDBF1

• Gene Name:

  DBF4

• UniProt:

  Q9UBU7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from N-terminal of human DBF4.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in testis and thymus. Expressed also in most cancer cells lines. .

• Applications:

  WB

• Field of Research:

  Cell Biology, Cell Cycle, DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, Kinases/Phosphatases

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  Western blotting: 1:500~1:3000

• Form:

  Liquid

• Function:

  Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. .

• Molecular Weight:

  76858 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Protein DBF4 homolog A

• Subcellular Location:

  Nucleus .