Quinidine hydrochloride monohydrate

• UNSPSC Description:

  Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM.

• Target Antigen:

  Parasite; Potassium Channel

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Quinidine_hydrochloride_monohydrate.html

• Purity:

  99.97

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 2.5 mg/mL (ultrasonic)

• Smiles:

  C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[H]Cl.[H]O[H]

• Molecular Weight:

  378.89

• References & Citations:

  [1]Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63.|[2]Cheng KI, et al. Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses. J Anesth. 2014 Aug;28(4):559-68.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  6151-40-2