NSE Antibody / Neuron Specific Enolase

• Description:

  This monoclonal antibody recognizes a protein of about 50kDa, which is identified as gamma-enolase. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found predominantly in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas.It it be usually employed in combination with other markers such as Synaptophysin, ?Chromogranin A, and Neurofilament.

• UniProt:

  P09104

• Host:

  Mouse

• Immunogen:

  A recombinant fragment of human NSE gamma (within amino acids 150-300) was used as the immunogen for the Gamma Enolase antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Aliquot the Gamma Enolase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Gamma Enolase antibody is available for research use only.

• CAS Number:

  9007-83-4