Topoisomerase IIα-IN-2

• UNSPSC Description:

  Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase[1].

• Target Antigen:

  Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/topoisomerase-iiα-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=NC=CC=C2C(C(OC3=C4)=C1)=NC3=CC=C4C(NCCCC[C@H](N)C(O)=O)=O

• Molecular Weight:

  420.42

• References & Citations:

  [1]Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2407521-90-6