Desethyl Amiodarone-d4 (hydrochloride)

• UNSPSC Description:

  Desethyl Amiodarone-d4 (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

• Target Antigen:

  Autophagy; Isotope-Labeled Compounds; Potassium Channel

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Autophagy;Membrane Transporter/Ion Channel;Others

• Field of Research:

  Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(I)=C(C(I)=C1)OC([2H])([2H])C([2H])([2H])NCC)C2=C(CCCC)OC3=CC=CC=C23.Cl

• Molecular Weight:

  657.74

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Shayeganpour A, et al. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34(1):43-50.|[3]Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67.|[4] Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1189960-80-2