GIRK2 Recombinant Rabbit Monoclonal Antibody [PSH05-91]

• Description:

  This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability.

• Product Name Alternative:

  inwardly rectifying subfamily J member 6 antibody BIR1 antibody G protein activated inward rectifier potassium channel 2 antibody G protein-activated inward rectifier potassium channel 2 antibody GIRK-2 antibody GIRK2 antibody hiGIRK2 antibody Inward rectifier K (+) channel Kir3.2 antibody Inward rectifier potassium channel KIR3.2 antibody KATP-2 antibody KATP2 antibody KCNJ6 antibody KCNJ6_HUMAN antibody Kcnj7 antibody KIR3.2 antibody KPLBS antibody Potassium channel antibody Potassium channel inwardly rectifying subfamily J member 6 antibody Potassium inwardly rectifying channel subfamily J member 6 antibody Potassium voltage gated channel subfamily J member 6 antibody

• Abbreviation:

  G protein-activated inward rectifier potassium channel 2 GIRK-2 BIR1 Inward rectifier K (+) channel Kir3.2 KATP-2 Potassium channel, inwardly rectifying subfamily J member 6 KCNJ6 GIRK2, KATP2, KCNJ7

• Swiss Prot:

  P48051 Human, P48542 Mouse, P48550 Rat

• Cellular Locus:

  Membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein.

• Isotype:

  IgG

• Clone:

  PSH05-91

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IHC-P, IP, IHC-Fr

• Positive Control:

  Mouse brain tissue lysate, mouse hippocampus tissue lysate, rat brain tissue lysate, rat hippocampus tissue lysate, human cerebellum tissue, mouse cerebellum tissue, rat cerebellum tissue, mouse brain tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000 ;IHC-P: 1:1,000 ;IP: 1-2μg/sample ;IHC-Fr: 1:200

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 48 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3