Bcl-6 (Follicular Lymphoma Marker)

• Gene Name:

  [Bcl-6]

• NCBI Gene ID:

  604

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of settings: (1) In the differential small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

• Other Gene Names:

  [BCL6; BCL6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; BCL5; LAZ3; ZBTB27; ZNF51; BCL-6; BCL-5]

• Short Name:

  [Bcl-6]

• Other Product Names:

  [B-cell lymphoma 6 protein isoform 1; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein; BCL6 transcription repressor; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51]

• NCBI GI Number:

  195927002

• NCBI Accession Number:

  NP_001124317.1

• NCBI GB Accession Number:

  NP_001124317.1

• Uniprot Accession Number:

  P41182