ERCC1/RAD10 (Tumor Progression Marker)

• Gene Name:

  [ERCC1]

• NCBI Gene ID:

  2067

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 110kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.

• Other Gene Names:

  [ERCC1; ERCC1; UV20; COFS4; RAD10]

• Short Name:

  [ERCC1/RAD10]

• Other Product Names:

  [DNA excision repair protein ERCC-1 isoform 3; DNA excision repair protein ERCC-1; DNA excision repair protein ERCC-1; ERCC excision repair 1, endonuclease non-catalytic subunit]

• NCBI GI Number:

  260593725

• NCBI Accession Number:

  NP_001159521.1

• NCBI GB Accession Number:

  NP_001159521.1

• Uniprot Accession Number:

  P07992