CD40 Ligand/CD154/TRAP1 (Activation Marker of T-Lymphocytes)

• Gene Name:

  [CD40LG]

• NCBI Gene ID:

  959

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positive CD40LG-positive T cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

• Other Gene Names:

  [CD40LG; CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L; CD40L; TNFSF5; TRAP; CD40-L; TRAP]

• Short Name:

  [CD40 Ligand/CD154/TRAP1]

• Other Product Names:

  [CD40 ligand; CD40 ligand; CD40 ligand; CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; TRAP]

• NCBI GI Number:

  4557433

• NCBI Accession Number:

  NP_000065.1

• NCBI GB Accession Number:

  NM_000074.2

• Uniprot Accession Number:

  P29965