Catenin, gamma (Cardiomyocyte Marker)

• Gene Name:

  [JUP]

• NCBI Gene ID:

  3728

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (alpha, beta, gamma and delta) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimers disease (LOAD) as well as to dilated cardiomyopathy.

• Other Gene Names:

  [JUP; JUP; DP3; PDGB; PKGB; CTNNG; DPIII; CTNNG; DP3]

• Short Name:

  [Catenin, gamma]

• Other Product Names:

  [junction plakoglobin; Junction plakoglobin; junction plakoglobin; junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3]

• NCBI GI Number:

  4504811

• NCBI Accession Number:

  NP_002221.1

• NCBI GB Accession Number:

  NM_002230.3

• Uniprot Accession Number:

  P14923