VEGFR-2-IN-53

• UNSPSC Description:

  VEGFR-2-IN-53 (Compound 15w) is a VEGFR-2 inhibitor with an IC50 of 4.34 μM. VEGFR-2-IN-53 induces apoptosis by inhibiting VEGFR-2 activity and preventing cell migration, thereby exhibiting anti-angiogenic effects. The IC50 value of VEGFR-2-IN-53 for inhibiting MCF-7 cell growth is 3.87 μM. VEGFR-2-IN-53 can be used in cancer research[1].

• Target Antigen:

  Apoptosis; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-in-53.html

• Smiles:

  O=C(NC1=NC2=C(C=CC=C2)S1)[C@H]3[C@H](C4=C(C)N(C5=CC=CC=C5)N=C4C)[C@@](C6=CC=CC=C6N7)3C7=O

• Molecular Weight:

  505.59

• References & Citations:

  [1]Valapil DG, et al. Design, development of pyrazole-linked spirocyclopropyl oxindole-carboxamides as potential cytotoxic agents and Type III allosteric VEGFR-2 inhibitors. ChemMedChem. 2024 Aug 1:e202400422.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported