BMS-599626 (Hydrochloride)
CAT:
804-HY-12010-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BMS-599626 (Hydrochloride)
- Product Name Alternative: AC480 (Hydrochloride)
- CAS Number: 873837-23-1
- UNSPSC Description: BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy[1][2].
- Target Antigen: EGFR
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/BMS-599626-Hydrochloride.html
- Purity: 99.68
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
- Molecular Weight: 567.01
- References & Citations: [1]Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.|[2]Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61.Life Sci. 2021 Dec 16;289:120231.|BMC Pulm Med. 2023 May 11;23(1):162.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 1