ZFYVE19 rabbit pAb

• Background:

  Disease:A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML) . Translocation t (11;15) (q23; q14) with MLL/HRX., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 FYVE-type zinc finger., tissue specificity:Detected in brain, heart, skeletal muscle, kidney and liver.

• Description:

  Disease: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t (11;15) (q23;q14) with MLL/HRX. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 FYVE-type zinc finger. tissue specificity: Detected in brain, heart, skeletal muscle, kidney and liver.

• Synonyms:

  ZFYVE19; MPFYVE; Zinc finger FYVE domain-containing protein 19; MLL partner containing FYVE domain

• Gene ID:

  84936

• UniProt:

  Q96K21

• Cellular Locus:

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human ZFYVE19. AA range:311-360

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  50kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  50 kD

• Subcellular Location:

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cleavage furrow . Midbody, Midbody ring . Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. .

• Other Product Names:

  ZFYVE19; MPFYVE; Zinc finger FYVE domain-containing protein 19; MLL partner containing FYVE domain

• Gene ID (Human):

  84936

• SwissProt (Human):

  Q96K21