AP2S1 Recombinant Rabbit Monoclonal Antibody [JE47-37]

AP2S1 Recombinant Rabbit Monoclonal Antibody [JE47-37]

• Description: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
• Product Name Alternative: Adapter-related protein complex 2 sigma subunit antibody Adaptor protein complex AP 2 subunit sigma antibody Adaptor protein complex AP-2 subunit sigma antibody Adaptor protein complex AP2 subunit sigma antibody Adaptor related protein complex 2 sigma 1 subunit antibody AI043088 antibody AP 17 antibody AP 2 complex subunit sigma 1 antibody AP-2 complex subunit sigma antibody AP17 antibody AP17 delta antibody AP2 complex subunit sigma 1 antibody Ap2s1 antibody AP2S1_HUMAN antibody CLAPS 2 antibody CLAPS2 antibody Clathrin adaptor complex AP2, sigma subunit antibody Clathrin adaptor protein AP17 antibody Clathrin assembly protein 2 small chain antibody Clathrin associated/assembly/adaptor protein small 2 antibody Clathrin associated/assembly/adaptor protein small 2, 17-KD antibody Clathrin associated/assembly/adaptor protein, small 2 (17kD) antibody Clathrin coat assembly protein AP17 antibody Clathrin coat associated protein AP17 antibody Clathrin coat-associated protein AP17 antibody HA2 17 kDa subunit antibody MGC62945 antibody Plasma membrane adaptor AP 2 17 kDa protein antibody Plasma membrane adaptor AP-2 17 kDa protein antibody Plasma membrane adaptor AP2 17 kDa protein antibody Sigma adaptin 3b antibody Sigma2 adaptin antibody Sigma2-adaptin antibody
• Abbreviation: AP-2 complex subunit sigma Adaptor protein complex AP-2 subunit sigma Adaptor-related protein complex 2 subunit sigma Clathrin assembly protein 2 sigma small chain Clathrin coat assembly protein AP17 Clathrin coat-associated protein AP17 HA2 17 kDa subunit Plasma membrane adaptor AP-2 17 kDa protein Sigma2-adaptin AP2S1 AP17, CLAPS2
• CAS Number: 9000-83-3
• Swiss Prot: P53680 Human, P62743 Mouse, P62744 Rat
• Cellular Locus: Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human AP2S1 aa 1-50 / 142.
• Isotype: IgG
• Clone: JE47-37
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: K-562 cell lysate, MCF7 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse spleen tissue lysate, rat kidney tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 17 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes