8-(N,N-Dimethylaminomethyl)guanosine

• UNSPSC Description:

  8-(N,N-Dimethylaminomethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/8-n-n-dimethylaminomethyl-guanosine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C(CN(C)C)=N2)C3=C2C(NC(N)=N3)=O)O1

• Molecular Weight:

  340.34

• References & Citations:

  [1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported