(10E,12E)-9-Oxo-10,12-octadecadienoic acid

• UNSPSC Description:

  (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity[1][2].

• Target Antigen:

  Fungal; PPAR

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/10e-12e-9-oxo-10-12-octadecadienoic-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC/C=C/C=C/C(CCCCCCCC(O)=O)=O

• Molecular Weight:

  294.43

• References & Citations:

  [1]Cantrell CL, et al. Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus. J Agric Food Chem. 2008 Jul 9;56(13):5062-8.|[2]Kim YI, et al. Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice. PLoS One. 2012;7(2):e31317.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  54232-58-5