Phosphatidylinositol 4,5-bisphosphate

• Product Name Alternative:

  2-APV (sodium); DL-2-Amino-5-phosphonovaleric acid (sodium), 2-APV (lithium); DL-2-Amino-5-phosphonovaleric acid (lithium)

• UNSPSC Description:

  Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate), a phospholipid component of cell membranes, is a substrate for phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) and as a primary messenger[1][2][3].

• Target Antigen:

  PI3K

• Type:

  Natural Products

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/phosphatidylinositol-4-5-bisphosphate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(O)O[C@H]1[C@@H]([C@H]([C@@H](O)[C@@H](OP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)(O)=O)[C@@H]1O)O)OP(O)(O)=O

• Molecular Weight:

  1047.09

• References & Citations:

  [1]Katan M, et, al. Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane. Essays Biochem. 2020 Sep 23;64(3):513-531. |[2]Arreola J, et, al. Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate Cell Calcium. 2019 Dec;84:102103. |[3]Kato M, et, al. Arabidopsis PCaP2 modulates the phosphatidylinositol 4,5-bisphosphate signal on the plasma membrane and attenuates root hair elongation. Plant J. 2019 Aug;99(4):610-625.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  245126-95-8