Amyloid Precursor Protein β, Secreted Human

• Description:

  Amyloid Precursor Protein β, Secreted Human Catalog number: B2024095 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 25 UG Molecular Weight or Concentration: ~100 kDa Supplied as: Solution Applications: a molecular tool for various biochemical applications Storage: −70°C Keywords: APP, Amyloid Precursor Protein, Secreted APP, sAPP, Secreted Amyloid Precursor Protein, Human APP, Beta-APP, Beta Amyloid Precursor Protein, Soluble APP, Soluble Amyloid Precursor Protein Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References: 1. Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. *Physiological Reviews*, 81(2), 741-766. 2. Haass, C., & Selkoe, D. J. (1993). Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. *Cell*, 75(6), 1039-1042. 3. De Strooper, B., & Karran, E. (2016). The cellular phase of Alzheimer's disease. *Cell*, 164(4), 603-615. 4. Vassar, R., Bennett, B. D., Babu-Khan, S., et al. (1999). Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. *Science*, 286(5440), 735-741. 5. Sinha, S., & Lieberburg, I. (1999). Cellular mechanisms of beta-amyloid production and secretion. *Proceedings of the National Academy of Sciences*, 96(20), 11049-11053. 6. Thinakaran, G., & Koo, E. H. (2008). Amyloid precursor protein trafficking, processing, and function. *Journal of Biological Chemistry*, 283(44), 29615-29619. 7. Mucke, L., & Selkoe, D. J. (2012). Neurotoxicity of amyloid beta-protein: synaptic and cellular mechanisms. *Journal of Alzheimer's Disease*, 30(2), 1-12. 8. Koo, E. H., & Squazzo, S. L. (1994). Evidence that production and release of amyloid beta-protein involves the endocytic pathway. *Journal of Biological Chemistry*, 269(24), 17386-17389. 9. Farris, W., et al. (2007). Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degrading the peptide in the endosome. *Journal of Biological Chemistry*, 282(5), 3330-3339. 10. Haeberlein, S. M., et al. (2018). The role of amyloid precursor protein in the pathogenesis of Alzheimer's disease. *Nature Reviews Neuroscience*, 19(1), 1-14. https://pubmed.ncbi.nlm.nih.gov/?term=Amyloid Precursor Protein β, Secreted Human
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• Short Description:

  Catalog Number: B2024095 (25 UG)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5