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Recombinant AMPK α1 Monoclonal Antibody

CAT: 0763-AN301102L-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0763-AN301102L-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Abbreviation
AMPK α1
UniProt
Q13131
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human AMPK α1 protein
Target
AMPK1; PRKAA1; Tau-protein kinase PRKAA1; HMGCR kinase; ACACA kinase; AMPK subunit alpha-1; AMPKα1
Clonality
Monoclonal, Recombinant
Clone
10F6
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Neuroscience; Signal Transduction; Cardiovascular; Cancer; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:100-200; WB 1:1000-5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
64 kDa
Observed Molecular Weight
64 kDa
Isotype
IgG, κ

UniProtKB · Q13131

5'-AMP-activated protein kinase catalytic subunit alpha-1

AAPK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13131
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKAA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
AMPK subunit alpha-1
EC number
2.7.11.1
Processing
—
Secondary accessions
A8MTQ6, B2R7E1, O00286, Q5D0E1, Q86VS1, Q9UNQ4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

AutophagyBiological rhythmsCholesterol biosynthesisCholesterol metabolismFatty acid biosynthesisFatty acid metabolismHost-virus interactionLipid biosynthesisLipid metabolismSteroid biosynthesisSteroid metabolismSterol biosynthesisSterol metabolismTranscriptionTranscription regulationWnt signaling pathway

Molecular function

Chromatin regulatorKinaseSerine/threonine-protein kinaseTransferase

Cellular component

CytoplasmEndosomeNucleus

PTM

GlycoproteinPhosphoproteinUbl conjugation

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