Recombinant SNCA/alpha-Synuclein Monoclonal Antibody

• Background:

  Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

• Abbreviation:

  SNCA

• UniProt:

  P37840

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant Human SNCA/alpha-Synuclein protein

• Target:

  Fetal liver kinase; Protein-tyrosine kinase receptor flk; Vascular endothelial growth factor receptor; PD1; NACP; PARK1; PARK4; SNCA; SNC-A; aSYN; CD309; Fetal liver kinase 1; FLK1; FLK-1; KDR; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; Vascular endothelial growth factor receptor 2; VEGFR; VEGFR2; VEGFR-2; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK1; alpha (non A4 component of amyloid precursor) ; Alpha synuclein; alphaSYN; isoform NACP140; Lewy body) 4; MGC105443; MGC110988; MGC127560; MGC64356; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; Non-A4 component of amyloid; Non-A-beta component of alzheimers disease amyloid; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 4; Parkinson disease (autosomal dominant; Parkinson disease familial 1; precursor of; Snca synuclein; SYN; Synuclein; Synuclein alpha; Synuclein alpha 140; SYUA

• Clonality:

  Monoclonal

• Clone:

  5D12

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Neuroscience

• Purification:

  Protein A

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  0.2 μm filtered solution in PBS

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  16 kDa

• Observed Molecular Weight:

  18 kDa

• Isotype:

  IgG