IL-7 Antibody [NYR-hi7]

• Background:

  Iterleukin 7 is a lymphoid cell growth factor that affects pre-B, pro-B, and early T cells. IL-7 was previously known as pre-B cell growth factor and lymphopoietin 1. IL-7 supports the growth of early B cells from long-term lymphoid bone marrow cultures. It is mitogenic to thymocytes and enhances the response of cells to other stimuli such as polyhydroxyalkanoate (PHA) and concanavalin A (ConA) . IL-7 stimulates the proliferation of CD4+/CD8+ cells. The proliferative response of thymocytes to IL-7 is not affected by antibodies to the T cell growth factors such as IL-2, IL-4 and IL-6, suggesting that IL-7 is capable of stimulating T cell proliferation through a pathway independent of the known T cell growth factors. Mature T cells respond to IL-7 and Con A, but not to IL-7 alone. In myeloid lineage cells, IL-7 upregulates the production of pro-inflammatory cytokines and stimulates the tumoricidal activity of monocytes/macrophages. IL-7 is expressed by adherent stromal cells from various tissues.

• NCBI Gene ID:

  3574

• Swiss Prot:

  P13232

• Accession Number:

  P13232

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  The monoclonal antibody was produced in BALB/c x C57BL/6 F1 mice using recombinant hIL-7 as the immunizing antigen.

• Clonality:

  Monoclonal

• Clone:

  NYR-hi7

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology, Chemokines & Cytokines

• Purification:

  This IgG1 antibody was purified from ascites fluid on a Protein A affinity column.

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  IL-7 lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20˚ C. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/mL. The antibody is stable for at least six weeks at 2-4˚ C when reconstituted.

• Symbol:

  IL7

• NCBI Official Name:

  Interleukin 7

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin 7Interleukin-7IL-7, IL-7

• Tested Applications:

  ELISA, WB, Neutralization Assay

• Protein ID:

  124354

• Physical Properties:

  Lyophilized