SARS-CoV-2 (COVID-19) Spike P26S Antibody [5G12G11] (Gamma Variant)

• Background:

  In January of 2021 a new lineage of SARS-CoV-2, known as P.1 and named Gamma variant, was discovered in Japan and later spread in Brazil. It is considered a VOC (variant of concern) . This variant carries 10 mutations in spike protein, including N501Y, E484K and K417T in RBD, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Gamma variant (P.1 lineage) was observed globally, which is 3.5 times more contagious as the original one. The Gamma variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent due to the immune escape E484K mutation.

• NCBI Gene ID:

  43740568

• Swiss Prot:

  P0DTC2

• Accession Number:

  QHD43416

• Host:

  Mouse

• Reactivity:

  Virus

• Immunogen:

  PM-9590

• Clonality:

  Monoclonal

• Clone:

  5G12G11

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  Anti-SARS-CoV-2 Spike P26S (Gamma Variant) antibody is immunoaffinity chromatography purified IgG.

• Concentration:

  1 mg/mL

• Homology:

  Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (36.4%)

• Buffer:

  SARS-CoV-2 Spike P26S (Gamma Variant) antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV-2 Spike P26S (Gamma Variant) antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Specificity:

  It can only detect SARS-CoV-2 Gamma Variant (P.1) Spike S1 protein and does not cross-react with the spike protein of other variants.

• Symbol:

  S

• NCBI Official Name:

  Surface glycoprotein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Voloch et al. Journal of Virology 2021, 95 (10) : e00119-21.

• Background Reference 02:

  Wang et al. Cell Host & Microbe 2021, 29 (5) : 747-751.

• Background Reference 03:

  Wang et al. Nature 592, 616-622.

• Other Product Names:

  SARS-CoV-2 Spike 156-157EF antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein

• Tested Applications:

  ELISA, WB

• Protein ID:

  1791269090

• Physical Properties:

  Liquid