Vinculin Antibody [7E10]

• Background:

  Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1) . Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2) . Expression of vinculin were shown to be affected by the level of actin expression (2,3) . Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4) . Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5) .

• NCBI Gene ID:

  7414

• Accession Number:

  NP_003364

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat, Rabbit, Chicken

• Clonality:

  Monoclonal

• Clone:

  [7E10]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  Vinculin antibody is purified via Protein A prification.

• Positive Control:

  Cat. No. 1216 - PC-3 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (100%)

• Buffer:

  Vinculin Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Vinculin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

• Symbol:

  VCL

• NCBI Official Name:

  Vinculin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Burridge et al. Annu. Rev. Cell Biol.1988; 4:487-525.

• Background Reference 02:

  Gilmore et al. J. Cell Sci. 1992; 103:719-31.

• Background Reference 03:

  Deakin et al. PLoS One 2012; 7:e37990.

• Background Reference 04:

  Goldmann et al. Cell Biol. Int. 2013; Feb 1.

• Other Product Names:

  CMD1W, CMH15, Metavinculin, MVCL

• Tested Applications:

  ELISA, WB

• Protein ID:

  4507877

• Physical Properties:

  Liquid