IL-21 Antibody [SB134b]

• Background:

  Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

• NCBI Gene ID:

  59067

• Swiss Prot:

  Q9HBE4

• Accession Number:

  Q9HBE4

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  E. coli-expressed human IL-21

• Clonality:

  Monoclonal

• Clone:

  [SB134b]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Chemokines & Cytokines

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2b

• Specificity:

  IL-21

• Applications Notes:

  IL-21 Antibody [SB134b] for use in ELISA assays.

• Symbol:

  IL21

• NCBI Official Name:

  Interleukin 21

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-21, Za11

• Tested Applications:

  ELISA, WB, IHC-P, IHC-Fr, ICC, Flow, IP, EM

• Physical Properties:

  Liquid