CD54 Antibody [15.2] (Biotin)

• Background:

  CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of CD54 are CD11a/LFA-1alpha and CD11b/Mac-1alpha. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC.

• NCBI Gene ID:

  3383

• Swiss Prot:

  P05362

• Accession Number:

  P05362

• Host:

  Mouse

• Reactivity:

  Human, Pig

• Immunogen:

  Rheumatoid synovial cells and human monocytes

• Clonality:

  Monoclonal

• Clone:

  [15.2]

• Conjugation:

  Biotin

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS/NaN3

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG1

• Specificity:

  CD54

• Applications Notes:

  CD54 Antibody [15.2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, and ELISA assays.

• Symbol:

  ICAM1

• NCBI Official Name:

  Intercellular adhesion molecule 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ICAM-1, intracellular adhesion molecule-1, Ly-47

• Tested Applications:

  Flow

• Physical Properties:

  Liquid