HER2 (phospho Tyr1112) Antibody

• Background:

  Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

• NCBI Gene ID:

  2064

• Swiss Prot:

  P04626

• Accession Number:

  NP_001005862.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  HER2 (phospho Tyr1112) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1112 (Q-R-Y (p) -S-E) derived from Human HER2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  150 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine 1112.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  ERBB2

• NCBI Official Name:

  V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chuang TD, et al. (2010) J Biol Chem 285, 23598-606

• Background Reference 02:

  Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Mol Cancer 8, 94

• Background Reference 03:

  Thelemann A, et al. (2005) Mol Cell Proteomics 4, 356-76

• Other Product Names:

  C-erbB-2, NGL, NEU proto-oncogene, MLN 19

• Tested Applications:

  WB

• Protein ID:

  54792098

• Physical Properties:

  Liquid