MuSK (phospho Tyr755) Antibody

• Background:

  Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.

• NCBI Gene ID:

  4593

• Swiss Prot:

  O15146

• Accession Number:

  NP_005583.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  MuSK (phospho Tyr755) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 755 (A-D-Y (p) -Y-K) derived from Human MuSK .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  97 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of MuSK only when phosphorylated at tyrosine 755.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  MUSK

• NCBI Official Name:

  Muscle, skeletal, receptor tyrosine kinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Valenzuela D.M., Neuron 15:573-584 (1995) .

• Background Reference 02:

  Humphray S.J., Nature 429:369-374 (2004) .

• Background Reference 03:

  Bergamin E., Mol. Cell 39:100-109 (2010) .

• Other Product Names:

  MUSK, Muscle, skeletal

• Tested Applications:

  WB

• Protein ID:

  5031927

• Physical Properties:

  Liquid