CD123 Antibody [6H6] (PE)

• Background:

  The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. CD123’s affinity to IL-3 is low, but increases when associated with CD131. It can be found on basophils, dendritic cells, macrophages, and mast cells.

• NCBI Gene ID:

  3563

• Swiss Prot:

  P26951

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  6H6

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell, Chemokines & Cytokines, Growth Factors

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor.

• Symbol:

  IL3RA

• NCBI Official Name:

  Interleukin 3 receptor, alpha (low affinity)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R., Strayer, D. S. (2009) . Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.Journal of General Virology,90 (3), 710-722.

• Background Reference 02:

  Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., ... Mackay, C. R. (1997) . Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.Journal of Clinical Investigation,99 (2), 178.

• Background Reference 03:

  Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., ... Sodroski, J. (1996) . The -beta--chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell,85 (7), 1135-1148.

• Other Product Names:

  IL3R, CD123, IL3RX, IL3RY, IL3RAY, hIL-3Ra, IL3RA

• Tested Applications:

  Flow

• Physical Properties:

  Liquid