IL-10 Antibody [3C12C12]

• Background:

  Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

• NCBI Gene ID:

  3586

• Swiss Prot:

  P22301

• Accession Number:

  P22301

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified recombinant human IL-10 expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  3C12C12

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Innate Immunity

• Purification:

  Antibody is purified by protein A affinity chromatography.

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody in PBS containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  To IL-10 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1.kappa

• Symbol:

  IL10

• NCBI Official Name:

  Interleukin 10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vieira P, et al. PNAS, 1991.88:1172-1176.

• Other Product Names:

  Cytokine synthesis inhibitory factor, IL-10, CSIF, TGIF, GVHDS, IL10A

• Tested Applications:

  ELISA, WB

• Protein ID:

  124292