FUT3 Antibody

• Background:

  FUT3 comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This protein is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha (1,3) -fucosyltransferase and alpha (1,4) -fucosyltransferase activities.

• NCBI Gene ID:

  2525

• Swiss Prot:

  P21217

• Accession Number:

  P21217

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FUT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-315 amino acids from the C-terminal region of human FUT3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  FUT3

• NCBI Official Name:

  Galactoside 3 (4) -L-fucosyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Park, H.D., et al. KoreanLab Med 30 (1) :51-57 (2010)

• Background Reference 02:

  Matzhold, E.M., et al. Transfusion 49 (10) :2097-2108 (2009)

• Background Reference 03:

  Norden, R., et al. Glycobiology 19 (7) :776-788 (2009)

• Background Reference 04:

  Liu, J., et al. J. Exp. Clin. Cancer Res. 28, 154 (2009)

• Other Product Names:

  Galactoside 3 (4) -L-fucosyltransferase, Blood group Lewis alpha-4-fucosyltransferase, Lewis FT, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, FT3B, LE

• Tested Applications:

  WB

• Protein ID:

  121137

• Physical Properties:

  Liquid