Germinal Center Kinase Antibody

• Background:

  The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

• NCBI Gene ID:

  5871

• Swiss Prot:

  Q12851

• Accession Number:

  Q12851

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Germinal Center Kinase (GCK/MAP4K2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-319 amino acids from the Central region of human Germinal Center Kinase (GCK/MAP4K2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  92 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAP4K2

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase kinase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chadee, D.N., et al., Mol. Cell. Biol. 22 (3) :737-749 (2002) .

• Background Reference 02:

  Katz, P., et al., J. Biol. Chem. 269 (24) :16802-16809 (1994) .

• Other Product Names:

  Mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein, MAP4K2, GCK, RAB8IP

• Tested Applications:

  WB, IHC-P

• Protein ID:

  215274019

• Physical Properties:

  Liquid