Chemokine Receptor D6 Antibody

• Background:

  CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

• NCBI Gene ID:

  1238

• Swiss Prot:

  O00590

• Accession Number:

  O00590

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Chemokine Receptor D6 (CCBP2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-84 amino acids from the N-terminal region of human Chemokine Receptor D6 (CCBP2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction, Growth Factors

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ACKR2

• NCBI Official Name:

  Atypical chemokine receptor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kunkel, E.J., et al., J. Clin. Invest. 111 (7) :1001-1010 (2003) .

• Background Reference 02:

  Fra, A.M., et al., J. Immunol. 170 (5) :2279-2282 (2003) .

• Background Reference 03:

  Soler, D., et al., Blood 101 (5) :1677-1682 (2003) .

• Background Reference 04:

  Nibbs, R.J., et al., Am. J. Pathol. 158 (3) :867-877 (2001) .

• Other Product Names:

  Atypical chemokine receptor 2, C-C chemokine receptor D6, Chemokine receptor CCR-10, Chemokine receptor CCR-9, Chemokine-binding protein 2, Chemokine-binding protein D6, ACKR2, CCBP2, CCR10, CMKBR9, D6

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid