RIC8A Antibody

• Background:

  Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex (By similarity) . Also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.

• NCBI Gene ID:

  60626

• Swiss Prot:

  Q9NPQ8

• Accession Number:

  Q9NPQ8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RIC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-272 amino acids from the Central region of human RIC8A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RIC8A

• NCBI Official Name:

  Synembryn-A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Woodard, G.E., et al. Mol. Cell. Biol. 30 (14) :3519-3530 (2010)

• Background Reference 02:

  Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)

• Background Reference 03:

  Lim, J., et al. Cell 125 (4) :801-814 (2006)

• Background Reference 04:

  Nishimura, A., et al. Genes Cells 11 (5) :487-498 (2006)

• Other Product Names:

  Synembryn-A, Protein Ric-8A, RIC8A

• Tested Applications:

  WB

• Protein ID:

  308153562

• Physical Properties:

  Liquid