PDZK1 Antibody

• Background:

  A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na (+) -dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity) .

• NCBI Gene ID:

  5174

• Swiss Prot:

  Q5T2W1

• Accession Number:

  Q5T2W1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDZK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human PDZK1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PDZK1

• NCBI Official Name:

  Na (+) /H (+) exchange regulatory cofactor NHE-RF3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  LaLonde, D.P., et al. Mol. Biol. Cell 21 (9) :1519-1529 (2010)

• Background Reference 03:

  Polasek, O., et al. Croat. Med. J. 51 (1) :32-39 (2010)

• Background Reference 04:

  Gunjaca, G., et al. Croat. Med. J. 51 (1) :23-31 (2010)

• Other Product Names:

  Na (+) /H (+) exchange regulatory cofactor NHE-RF3, NHERF-3, CFTR-associated protein of 70 kDa, Na (+) /H (+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3, PDZK1, CAP70, NHERF3, PDZD1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  73621372

• Physical Properties:

  Liquid