Tau (phospho Ser416) Antibody

• Background:

  Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985) . Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990) . Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995) . Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990) .

• NCBI Gene ID:

  29477

• Swiss Prot:

  P19332

• Accession Number:

  P19332

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Bovine, Chicken

• Immunogen:

  Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of rat tau.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Phospho-Specific

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Tau (Ser416) antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  59/65/68

• Specificity:

  Specific for ~59, 65, 68k tau protein phosphorylated at Ser416.

• Symbol:

  Mapt

• NCBI Official Name:

  Microtubule-associated protein tau

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Bio Oct; 101 (4) :1371-8.

• Background Reference 02:

  Lee V.M.Y. (1995) Disruption of the cytoskeleton in Alzheimer’s disease. Curr. Opin. Neurobiol. 5, 663-668.

• Background Reference 03:

  Goedert M. and Jakes R. (1990) Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9, 4225-4230.

• Background Reference 04:

  Steiner B., Mandelkow E.M., Biernat J. et al. (1990) Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2+-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J. 9, 3539-3544.

• Tested Applications:

  WB

• Protein ID:

  13432197

• Physical Properties:

  Liquid