GABAB Receptor (phospho Ser923) Antibody

• Background:

  Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004) . Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.

• NCBI Gene ID:

  81657

• Swiss Prot:

  Q9Z0U4

• Accession Number:

  Q9Z0U4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Bovine

• Immunogen:

  Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific, Neuroscience

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GABAB Receptor antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  102

• Applications Notes:

  The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

• Symbol:

  Gabbr1

• NCBI Official Name:

  Gamma-aminobutyric acid (GABA) B receptor 1

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Couve A, Calver AR, Fairfax B, Moss SJ, Pangalos MN (2004) Unravelling the unusual signaling proerties of the GABA (B) receptor. Biochem. Pharmacol. Oct 12;68 (8) :1527-36.

• Tested Applications:

  WB

• Protein ID:

  12643494

• Physical Properties:

  Liquid