Huntington Protein Antibody

• Background:

  Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington’s disease protein is ~350 kDa in size and is localized in the brain.

• NCBI Gene ID:

  3064

• Swiss Prot:

  P42858

• Accession Number:

  AAB38240

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to the N-terminus.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Dry Ice

• Fragment:

  IgG

• Applications Notes:

  ELISA, Western (immuno) blotting, Immunostaining (in testing)

• Symbol:

  HTT

• NCBI Official Name:

  Huntingtin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Huntington's disease: from pathology and genetics to potential therapies. Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Biochem J. 2008 Jun 1;412 (2) :191-209

• Background Reference 02:

  Huntington disease models and human neuropathology: similarities and differences. Vonsattel JP. Acta Neuropathol. 2008 Jan;115 (1) :55-69

• Background Reference 03:

  CHD proteins: a diverse family with strong ties. Hall JA, Georgel PT. Biochem Cell Biol. 2007 Aug;85 (4) :463-76

• Background Reference 04:

  Characterization and localization of the Huntington disease gene product. André T. Hoogeveen*, Rob Willemsen, Nicolle Meyer, Karien E.de Roolj1, Raymund A.C. Roos2, Gert-Jan B.van Ommen1 and Hans Galjaard, Hum Mol Genet. 1993 Dec;2 (12) :2069-73

• Other Product Names:

  HD, IT15, HD

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  296434520

• Physical Properties:

  Liquid