CD40 Antibody [FGK45] (preservative free)

• Background:

  CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

• NCBI Gene ID:

  21939

• Swiss Prot:

  P27512

• Accession Number:

  172046819

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  Recombinant mouse CD40 fusion protein.

• Clonality:

  Monoclonal

• Clone:

  FGK45

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Cancer, Immunology, Innate Immunity

• Purification:

  >95% (SDS-PAGE)

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. In PBS. Preservative free formulation.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG2a

• Specificity:

  Recognizes mouse CD40.

• Applications Notes:

  Functional Application: Activates B and NK cells in vivo and in vitro.

• Symbol:

  Cd40

• NCBI Official Name:

  CD40 antigen

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor

• Tested Applications:

  Flow, Functional Assays

• Protein ID:

  P27512

• Physical Properties:

  Liquid