FIP1L1 Antibody

• Background:

  FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly (A) polymerase and other factors to bring about cleavage and poly (A) addition. FIP1L1 contributes to poly (A) site recognition and stimulates poly (A) addition. It binds to U-rich RNA sequence elements surrounding the poly (A) site. FIP1L1 may act to tether poly (A) polymerase to the CPSF complex.

• NCBI Gene ID:

  81608

• Swiss Prot:

  Q6UN15

• Accession Number:

  NP_112179

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FIP1L1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store FIP1L1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  65 kDa

• Applications Notes:

  FIP1L1 antibody can be used for detection of FIP1L1 by ELISA at 1:62500. FIP1L1 antibody can be used for detection of FIP1L1 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  FIP1L1

• NCBI Official Name:

  Factor interacting with PAPOLA and CPSF1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhao, X., (2005) J. Virol. 79 (7), 4270-4288.

• Other Product Names:

  FIP1L1, DKFZp586K0717, FLJ33619, Rhe, FIP1, hFip1

• Tested Applications:

  ELISA, WB

• Protein ID:

  40254978

• Physical Properties:

  Liquid