Histone H2A.Z Antibody

• Background:

  Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

• NCBI Gene ID:

  3015

• Swiss Prot:

  P0C0S5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human H2AFZ (NP_002097.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HL-60

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 15kDa

• Fragment:

  IgG

• Symbol:

  H2AFZ

• Positive Control 2:

  MCF7

• Positive Control 3:

  22Rv1

• Positive Control 4:

  PC-12

• Positive Control 5:

  HepG2

• Positive Control 6:

  Mouse testis

• NCBI Official Name:

  Histone H2A.Z

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Histone H2AZ, H2A/z, H2AFZ, H2AZ

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid