ZC3H12A (CT) Antibody

• Background:

  ZC3H12A Antibody: ZC3H12A is an MCP1 (CCL2; MIM 158105) -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis. ZC3H12A inhibits the Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs. ZC3H12A ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells. ZC3H12A is a novel link between diabetogenic conditions and impaired insulin secretory capacity. ZC3H12A overexpression in human neuroblastoma cell lines causes cell-cycle arrest by G1/S checkpoint block.

• NCBI Gene ID:

  80149

• Swiss Prot:

  Q5D1E8

• Accession Number:

  Q5D1E7.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  9547

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  ZC3H12A Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1701-01 - Human Lung Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Chimpanzee (100%) ; Monkey (100%) ; Pig (79%) ; Chicken (83%)

• Buffer:

  ZC3H12A Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZC3H12A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Human ZC3H12A has one isoform (599aa, 65.7kD) . Mouse has one isoform (596aa, 65.6kD) . Rat has one isoform (596aa, 65.9kD) . 9547 can detect ZC3H12A in human, mouse, and rat.

• Symbol:

  ZC3H12A

• Positive Control 2:

  Cat. No. 11-701 - Human Testis Tissue Slide

• NCBI Official Name:

  Zinc finger CCCH-type containing 12A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gorka et al. Oncogene. 2021; 40 (50) :6720-6735

• Background Reference 02:

  Nowak et al. RNA Biol. 2021; 18 (1) :144-156

• Background Reference 03:

  Tyka et al. Biochim Biophys Acta Mol Basis Dis. 2021; 1867 (10) :166199

• Background Reference 04:

  Boratyn et al. J Cell Biochem. 2020; 121 (5-6) ;3406-3425

• Other Product Names:

  ZC3H12A Antibody: Endoribonuclease ZC3H12A, Monocyte chemotactic protein-induced protein 1, MCP-induced protein 1, MCPIP-1, Zinc finger CCCH domain-containing protein 12A

• Tested Applications:

  ELISA, WB, IF, IHC

• Protein ID:

  190485853

• Physical Properties:

  Liquid