Betatrophin Antibody

• Background:

  The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels (1,2) . Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis (3) .

• NCBI Gene ID:

  55908

• Swiss Prot:

  Q6UXH0

• Accession Number:

  NP_061157

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  Betatrophin antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  Betatrophin antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Betatrophin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  Betatrophin antibody is human, mouse and rat reactive. At least three isoforms of Betatrophin are known to exist; this antibody will detect the two largest isoforms.

• Symbol:

  C19orf80

• NCBI Official Name:

  Chromosome 19 open reading frame 80

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ren G, Kim JY, and Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am. J. Endocrinol. Metab. 2012; 303:E334-51.

• Background Reference 02:

  Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem. Biophys. Res. Commun. 2012; 424:786-92.

• Background Reference 03:

  Fu Z, Yao F, Abou-Samra AB, et al. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem. Biophys. Res. Commun. 2013; 430:1126-31.

• Other Product Names:

  Betatrophin Antibody: RIFL, TD26, ANGPTL8, PRO1185, PVPA599, Angptl8, UNQ599/PRO1185, Betatrophin, Angiopoietin-like protein 8

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  291219911

• Physical Properties:

  Liquid