Cathelicidin Antibody

• Background:

  Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.

• NCBI Gene ID:

  820

• Swiss Prot:

  P49913

• Accession Number:

  NP_004336

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  Cathelicidin Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  Cathelicidin Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Cathelicidin antibody can be stored at 4˚ C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  CAMP

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Cathelicidin antimicrobial peptide

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zaiou M and Gallo RL. Cathelicidins, essential gene-encoded mammalian antibiotics. J. Mol. Med. 2002; 80:549-61.

• Background Reference 02:

  Agerberth B, Gunne H, Odeberg J, et al. FALL-39, a Putative Human Peptide Antibiotic, is Cysteine-Free and Expressed in Bone Marrow and Testis. Proc. Natl. Acad. Sci. USA 1995; 92:195-9.

• Background Reference 03:

  Nizet V, Ohtake T, Lauthe X, et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414:454-7.

• Background Reference 04:

  Koczulla R, von Degenfeld G, Kupatt C, et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 2003; 111:1665-72.

• Other Product Names:

  Cathelicidin Antibody: LL37, CAP18, CRAMP, HSD26, CAP-18, FALL39, FALL-39, Cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  39753970

• Physical Properties:

  Liquid