GFR alpha 1 Antibody

• Background:

  GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα -1 recently. GFRα -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK) . Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

• NCBI Gene ID:

  2674

• Swiss Prot:

  P56159

• Accession Number:

  P56159

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Growth Factors, Neuroscience

• Purification:

  GFR alpha 1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  GFR alpha 1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GFR alpha 1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  IgG

• Specificity:

  GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

• Symbol:

  GFRA1

• Positive Control 2:

  Cat. No. 1304 - Human Liver Tissue Lysate

• Positive Control 3:

  Cat. No. 1305 - Human Kidney Tissue Lysate

• Positive Control 4:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Positive Control 5:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  GDNF family receptor alpha 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jing S, Wen D, Yu Y, et al. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-a, a novel receptor for GDNF. Cell 1996; 85:1113-24.

• Background Reference 02:

  Treanor JJS, Goodman L, Sauvage FD, et al. Characterization of a multicomponent receptor for GDNF. Nature 1996;82:80-83.

• Background Reference 03:

  Sanicola M, Hession C, Worley D, et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc. Natl. Acad. Sci. USA 1997; 94:6238-43.

• Background Reference 04:

  Buj-Bello A, Adu J, Pinon LG, et al. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997; 387:721-4

• Other Product Names:

  GFR alpha 1 Antibody: GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1, GDNF family receptor alpha-1, RET ligand 1, GDNF receptor alpha-1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  20141405

• Physical Properties:

  Liquid