Dis3l2 (NM_153530) Mouse Recombinant Protein

• Background:

  3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  4930429A22Rik; 8030493P09Rik

• Gene ID:

  208718

• UniProt:

  Q8CI75

• Accession Number mRNA:

  NM_153530

• Chromosomal Location:

  1 C5

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  97.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Dis3l2

• Species:

  Mouse

• Protein ID:

  NP_705758

• Overview:

  Purified recombinant protein of Mouse DIS3 like 3'-5' exoribonuclease 2 (Dis3l2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/208718

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8CI75

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_153530

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_705758