Sorbitol Dehydrogenase (SORD) (NM_003104) Human Recombinant Protein

• Background:

  Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]) . The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.[supplied by OMIM, Jul 2010]

• Synonyms:

  HEL-S-95n; RDH; SDH; SORD1; SORDD; XDH

• Gene ID:

  6652

• UniProt:

  Q00796

• Accession Number mRNA:

  NM_003104

• Chromosomal Location:

  15q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Fructose and mannose metabolism, Metabolic pathways

• Field of Research:

  Fructose and mannose metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  38.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SORD

• Species:

  Human

• Protein ID:

  NP_003095

• Overview:

  Recombinant protein of human sorbitol dehydrogenase (SORD)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6652

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q00796

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003104

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003095