COX7C (NM_001867) Human Recombinant Protein

• Background:

  Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

• Synonyms:

  Cytochrome-c oxidase chain VIIc; cytochrome c oxidase subunit VIIc

• Gene ID:

  1350

• UniProt:

  P15954

• Accession Number mRNA:

  NM_001867

• Chromosomal Location:

  5q14.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

• Field of Research:

  Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  5.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  COX7C

• Species:

  Human

• Protein ID:

  NP_001858

• Overview:

  Recombinant protein of human cytochrome c oxidase subunit VIIc (COX7C), nuclear gene encoding mitochondrial protein

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1350

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15954

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001867

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001858