RING1 (NM_002931) Human Recombinant Protein

• Background:

  This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

• Synonyms:

  RING1A; RNF1

• Gene ID:

  6015

• UniProt:

  Q06587, A0A1U9X8F2

• Accession Number mRNA:

  NM_002931

• Chromosomal Location:

  6p21.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  42.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RING1

• Species:

  Human

• Protein ID:

  NP_002922

• Overview:

  Recombinant protein of human ring finger protein 1 (RING1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6015

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q06587

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002931

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002922